同基因小鼠对通过诱变恶性畸胎瘤细胞系获得的细胞变体的排斥反应。
Rejection by syngeneic mice of cell variants obtained by mutagenesis of a malignant teratocarcinoma cell line.
作者信息
Boon T, Kellermann O
出版信息
Proc Natl Acad Sci U S A. 1977 Jan;74(1):272-5. doi: 10.1073/pnas.74.1.272.
Abstract
Cells from the malignant teratocarcinoma line PCC4.azal were treated with the mutagen N-methyl-N'-nitro-N-nitrosoguanidine. Fifty-five clones were isolated from the surviving cells. Twelve clones are unable to form tumors in the syngeneic 129/Sv mice. However, these "tum-" clones form tumors as readily as the original cells when they are injected into irradiated mice. Moreover, they stimulate the production of immune memory cells, which protect the injected animals and confer resistance by adoptive transfer. The tum- clones are therefore unable to generate tumors in syngeneic mice because they elicit an immune rejection response.
摘要
来自恶性畸胎瘤细胞系PCC4.azal的细胞用诱变剂N-甲基-N'-硝基-N-亚硝基胍处理。从存活细胞中分离出55个克隆。12个克隆在同基因的129/Sv小鼠中无法形成肿瘤。然而，当将这些“tum-”克隆注射到受辐照小鼠体内时，它们形成肿瘤的能力与原始细胞一样强。此外，它们刺激免疫记忆细胞的产生，这些细胞保护注射的动物并通过过继转移赋予抵抗力。因此，tum-克隆在同基因小鼠中无法产生肿瘤，因为它们引发了免疫排斥反应。
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