McArdle Laboratory for Cancer Research, The University of Wisconsin. Madison, Wisconsin 53706, USA.
Immunogenetics. 1980;10(4):383-93. doi: 10.1007/BF01561588.
Resistance to two cultured lines of murine embryonal carcinoma was studied in F1 hybrids constructed between the tumor-syngeneic mouse strain 129/J and several allogeneic strains. Three of four such hybrid strains were significantly more resistant to the multipotent embryonal carcinoma line PCC3 than the tumor-syngeneic 129/J parent strain. All hybrid strains tested showed significantly higher resistance to the nullipotent embryonal carcinoma line F9 than the syngeneic strain. Hybrid resistance to embryonal carcinoma lines does not require a hybrid H-2 complex. Several kinds of evidence indicate that this hybrid resistance has an immunological basis.
研究了在肿瘤同系鼠 129/J 与几种同种异体系之间构建的 F1 杂种中，对两种培养的鼠胚癌细胞系的抗性。在四个杂种系中，有三个杂种系对多能胚癌细胞系 PCC3 的抗性明显高于肿瘤同系 129/J 亲本系。所有测试的杂种系对同基因系 F9 的无潜能胚癌细胞系的抗性均明显高于同基因系。杂种对胚癌细胞系的抗性不需要杂种 H-2 复合物。有几种证据表明这种杂种抗性具有免疫学基础。
