Houghton Alan N, Guevara-Patiño José A
The Swim Across America Laboratory of Tumor Immunology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
J Clin Invest. 2004 Aug;114(4):468-71. doi: 10.1172/JCI22685.
Most antigens expressed by human cancer cells and recognized by host T cells and antibodies are nonmutated self antigens — molecules also expressed on the surface of normal cells. These self antigens are ineffective at triggering immune responses against cancer cells, which provides one explanation for the difficulties in trying to immunize against human cancer. A new study describes how tumors can avoid recognition by the immune system and how enhancing the affinity of the interaction between a self antigen and the MHC-I molecule may lead to cancer immunity.
大多数由人类癌细胞表达并被宿主T细胞和抗体识别的抗原都是未突变的自身抗原——这些分子也在正常细胞表面表达。这些自身抗原在触发针对癌细胞的免疫反应方面无效，这为试图对人类癌症进行免疫接种所面临的困难提供了一种解释。一项新的研究描述了肿瘤如何避免被免疫系统识别，以及增强自身抗原与MHC-I分子之间相互作用的亲和力如何可能导致癌症免疫。
