钙泄漏是自发性高血压大鼠血管平滑肌静息张力升高的原因。
Calcium leakage as a cause of the high resting tension in vascular smooth muscle from the spontaneously hypertensive rat.
作者信息
Noon J P, Rice P J, Baldessarini R J
出版信息
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1605-7. doi: 10.1073/pnas.75.3.1605.
Abstract
Aortic strips from spontaneously hypertensive (SH) rats relax in calcium-free physiological medium and contract to approximately 60% of maximum when calcium is again restored to the medium. In vivid contrast, the resting tension of aortic strips from normal rats is unaffected by manipulation of the calcium concentration of the bathing medium. These findings, as well as the reduced sensitivity of aortic strips from SH rats to norepinephrine and the observation that aortic strips from SH rats relax at a faster rate in calcium-free medium in comparison with aortic strips from normal rats, are consistent with the hypothesis that vascular smooth muscle membranes from SH rats leak calcium at a rate that is only partially compensated by the calcium pump.
摘要
来自自发性高血压（SH）大鼠的主动脉条在无钙生理介质中松弛，当介质中再次恢复钙时，收缩至最大收缩力的约60%。与之形成鲜明对比的是，正常大鼠主动脉条的静息张力不受浴液钙浓度变化的影响。这些发现，以及SH大鼠主动脉条对去甲肾上腺素的敏感性降低，还有与正常大鼠主动脉条相比，SH大鼠主动脉条在无钙介质中松弛速度更快的观察结果，都与以下假设一致：SH大鼠的血管平滑肌膜以一定速率泄漏钙，而钙泵只能部分补偿这种泄漏。
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本文引用的文献
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