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发育遗传学中的非昆虫甲壳类动物模型,包括对夏威夷半海虾的赞词。

Non-insect crustacean models in developmental genetics including an encomium to Parhyale hawaiensis.

作者信息

Stamataki Evangelia, Pavlopoulos Anastasios

机构信息

Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.

Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.

出版信息

Curr Opin Genet Dev. 2016 Aug;39:149-156. doi: 10.1016/j.gde.2016.07.004. Epub 2016 Jul 29.

Abstract

The impressive diversity of body plans, lifestyles and segmental specializations exhibited by crustaceans (barnacles, copepods, shrimps, crabs, lobsters and their kin) provides great material to address longstanding questions in evolutionary developmental biology. Recent advances in forward and reverse genetics and in imaging approaches applied in the amphipod Parhyale hawaiensis and other emerging crustacean model species have made it possible to probe the molecular and cellular basis of crustacean diversity. A number of biological and technical qualities like the slow tempo and holoblastic cleavage mode, the stereotypy of many cellular processes, the functional and morphological diversity of limbs along the body axis, and the availability of various experimental manipulations, have made Parhyale a powerful system to study normal development and regeneration.

摘要

甲壳类动物(藤壶、桡足类动物、虾、蟹、龙虾及其同类)展现出令人印象深刻的身体结构、生活方式和体节特化的多样性,为解答进化发育生物学中由来已久的问题提供了丰富的素材。在夏威夷草钩虾和其他新兴的甲壳类模式物种中应用的正向和反向遗传学以及成像方法的最新进展,使得探究甲壳类动物多样性的分子和细胞基础成为可能。诸如发育节奏缓慢和全裂卵裂模式、许多细胞过程的刻板性、沿身体轴线肢体的功能和形态多样性以及各种实验操作的可行性等一系列生物学和技术特性,使草钩虾成为研究正常发育和再生的强大系统。

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