Alger J R, Brunetti A, Nagashima G, Hossmann K A
Neuroimaging Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892.
Magn Reson Med. 1989 Jul;11(1):73-84. doi: 10.1002/mrm.1910110107.
The use of a water-suppressing spin-echo pulse sequence reported recently (V. Sklenar and A. Bax, J. Magn. Reson. 74, 469 (1987); M. von Kienlin, M. DeCorps, J. P. Albrand, M. F. Foray, and P. Blondet, J. Magn. Reson. 76, 169 (1987)) was evaluated for in vivo brain proton surface coil NMR spectroscopy. The studies were performed on cat brain using surface coils at 4.7 T. The sequence produced brain spectra with adequate water suppression, and a broader excitation profile than sequences which form spin echoes using 1331 pulses (P. J. Hore, J. Magn. Reson. 54, 539 (1983); H. P. Hetherington, M. J. Avison, and R. G. Shulman, Proc. Natl. Acad. Sci. USA 82, 3115 (1985)). The phase artifacts were smaller than those produced in 1331 methods, but theoretical analysis showed they should not be completely absent. The effectiveness of lengthening the spin-echo delay in the new sequence for suppression of unwanted lipid resonances was demonstrated. The sequence was shown to be capable of detecting lactate formation and clearance in a global cerebral ischemia experiment.
最近报道的一种抑制水的自旋回波脉冲序列（V. Sklenar和A. Bax，《磁共振杂志》74, 469 (1987)；M. von Kienlin、M. DeCorps、J. P. Albrand、M. F. Foray和P. Blondet，《磁共振杂志》76, 169 (1987)）被用于活体脑质子表面线圈核磁共振波谱分析的评估。研究在4.7T场强下使用表面线圈对猫脑进行。该序列产生的脑波谱具有足够的水抑制效果，并且与使用1331脉冲形成自旋回波的序列相比，激发谱更宽（P. J. Hore，《磁共振杂志》54, 539 (1983)；H. P. Hetherington、M. J. Avison和R. G. Shulman，《美国国家科学院院刊》82, 3115 (1985)）。相位伪影比1331方法产生的要小，但理论分析表明它们不应完全不存在。新序列中延长自旋回波延迟对抑制不需要的脂质共振的有效性得到了证明。该序列被证明能够在全脑缺血实验中检测乳酸的形成和清除。
