Bourgeois D, Kozlowski P
Institute for Biodiagnostics, National Research Council of Canada, Ottawa, Ontario.
Magn Reson Med. 1993 Mar;29(3):402-6. doi: 10.1002/mrm.1910290320.
A lactate editing sequence based on the use of spin-locking pulses with surface coils is described. The sequence retains more than 90% of the available lactate magnetization and suppresses at least 95% of the lipid signal in a single scan and ca. 99.5% after a simple two step cycle. The technique allows simultaneous observation of lactate and uncoupled metabolites in the range 2 to 3 ppm. The sequence was combined with two-dimensional spectroscopic imaging to obtain a lactate map of an ischemic rat brain in vivo.
描述了一种基于使用表面线圈的自旋锁定脉冲的乳酸编辑序列。该序列在单次扫描中保留了超过90%的可用乳酸磁化强度，并抑制了至少95%的脂质信号，经过简单的两步循环后抑制率约为99.5%。该技术能够同时观察2至3 ppm范围内的乳酸和未偶联代谢物。该序列与二维光谱成像相结合，以获得活体缺血大鼠脑的乳酸图谱。
