Rémy B, Plener L, Elias M, Daudé D, Chabrière E
IRD 198, Inserm 1095, URMITE, UM63, CNRS 7278, Aix Marseille université, 13385 Marseille cedex 05, France; Gene&GreenTK, faculté de médecine, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France.
Gene&GreenTK, faculté de médecine, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France.
Ann Pharm Fr. 2016 Nov;74(6):413-420. doi: 10.1016/j.pharma.2016.06.005. Epub 2016 Jul 27.
Quorum sensing (QS) is used by bacteria to communicate and synchronize their actions according to the cell density. In this way, they produce and secrete in the surrounding environment small molecules dubbed autoinducers (AIs) that regulate the expression of certain genes. The phenotypic traits regulated by QS are diverse and include pathogenicity, biofilm formation or resistance to anti-microbial treatments. The strategy, aiming at disrupting QS, known as quorum quenching (QQ), has emerged to counteract bacterial virulence and involves QS-inhibitors (QSI) or QQ-enzymes degrading AIs. Differently from antibiotics, QQ aims at blocking cell signaling and does not alter bacterial survival. This considerably decreases the selection pressure as compared to bactericide treatments and may reduce the occurrence of resistance mechanisms. QQ-enzymes are particularly appealing as they may disrupt molecular QS-signal without entering the cell and in a catalytic way. This review covers several aspects of QQ-based medical applications and the potential subsequent emergence of resistance is discussed.
群体感应（QS）是细菌用于根据细胞密度进行通讯和同步行动的方式。通过这种方式，它们在周围环境中产生并分泌被称为自诱导物（AIs）的小分子，这些小分子调节某些基因的表达。由群体感应调节的表型特征多种多样，包括致病性、生物膜形成或对抗菌治疗的抗性。旨在破坏群体感应的策略，即群体猝灭（QQ），已出现以对抗细菌毒力，它涉及群体感应抑制剂（QSI）或降解自诱导物的群体猝灭酶。与抗生素不同，群体猝灭旨在阻断细胞信号传导，而不会改变细菌的存活。与杀菌剂处理相比，这大大降低了选择压力，并可能减少耐药机制的出现。群体猝灭酶特别有吸引力，因为它们可能以催化方式在不进入细胞的情况下破坏分子群体感应信号。本综述涵盖了基于群体猝灭的医学应用的几个方面，并讨论了随后可能出现的耐药性。
