da Rosa Maria Inês, Simon Carla, Grande Antonio Jose, Barichello Tatiana, Oses Jean Pierre, Quevedo João
Laboratório de Epidemiologia, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil; Programa de Pós-Graduação em Saúde Coletiva, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil; Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
Laboratório de Epidemiologia, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
J Affect Disord. 2016 Dec;206:210-215. doi: 10.1016/j.jad.2016.07.030. Epub 2016 Jul 19.
Bipolar disorder (BD) is a neuropsychiatric disorder characterized by recurrent episodes of mania/hypomania, affecting more than 1% of the world population. S100B is a calcium-binding protein, mostly produced and secreted by astrocytes in the CNS that participate in several cellular responses. Previous studies have shown that patients with bipolar disorder had higher peripheral S100B levels than healthy individuals, suggesting a potential role for S100B BD.
In this study, a systematic and quantitative meta-analysis of studies S100B serum was performed according to the guidelines PRISMA-statement to confirm the increase of serum S100B in patients with manic bipolar disorder.
We included in the meta-analysis two studies that reported the mean and standard deviation of serum S100B 52 patients manic BP and 52 control studies. Our results showed higher levels of S100B peripheral TB patients compared with healthy controls. In this meta-analysis, we found evidence that serum S100B are increased in patients with bipolar disorder.
In conclusion, several studies have observed morphological abnormalities in the brains of bipolar disorder patients, changes in the peripheral S100B levels in mood disorders were described, and this protein could be a putative marker for damage to the brain. Thus, in this meta-analysis we have found evidence, based on two studies of 52 patients and 52 healthy controls, that the serum concentrations of S100B are increased in bipolar disorder patients.
双相情感障碍（BD）是一种神经精神疾病，其特征为躁狂/轻躁狂发作反复出现，影响着全球超过1%的人口。S100B是一种钙结合蛋白，主要由中枢神经系统中的星形胶质细胞产生和分泌，参与多种细胞反应。先前的研究表明，双相情感障碍患者的外周血S100B水平高于健康个体，提示S100B在双相情感障碍中可能发挥作用。
在本研究中，根据PRISMA声明指南对S100B血清研究进行了系统的定量荟萃分析，以证实双相躁狂症患者血清S100B升高。
我们在荟萃分析中纳入了两项报告血清S100B均值和标准差的研究，涉及52例双相躁狂症患者和52例对照研究。我们的结果显示，与健康对照相比，双相情感障碍患者外周血S100B水平更高。在这项荟萃分析中，我们发现有证据表明双相情感障碍患者血清S100B升高。
总之，多项研究观察到双相情感障碍患者大脑存在形态学异常，描述了情绪障碍中外周血S100B水平的变化，且这种蛋白可能是脑损伤的一个推定标志物。因此，在这项荟萃分析中，基于两项涉及52例患者和52例健康对照的研究，我们发现有证据表明双相情感障碍患者血清S100B浓度升高。
