Calame Daniel G, Mueller-Ortiz Stacey L, Wetsel Rick A
The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States; University of Texas McGovern Medical School at Houston, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, United States.
The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States.
Immunobiology. 2016 Dec;221(12):1407-1417. doi: 10.1016/j.imbio.2016.07.004. Epub 2016 Jul 16.
Listeria monocytogenes is a leading cause of foodborne-illness associated mortality that has attracted considerable attention in recent years due to several significant outbreaks. It has also served as a model organism for the study of intracellular pathogens. For these reasons the host response to L. monocytogenes has long been the subject of investigation. A potent innate and adaptive immune response is required for containment and clearance of L. monocytogenes. However, some elements of this response, such as type 1 interferons, can be detrimental to the host. Recent studies have revealed novel functions for the complement system, an ancient arm of innate immunity, in this process. Here we review the role of complement in the host response to L. monocytogenes.
单核细胞增生李斯特菌是食源性疾病相关死亡的主要原因，近年来由于几次重大疫情爆发而备受关注。它也一直作为研究细胞内病原体的模式生物。基于这些原因，宿主对单核细胞增生李斯特菌的反应长期以来一直是研究的主题。控制和清除单核细胞增生李斯特菌需要强大的先天性和适应性免疫反应。然而，这种反应的某些成分，如1型干扰素，可能对宿主有害。最近的研究揭示了补体系统（先天性免疫的一个古老分支）在此过程中的新功能。在此，我们综述补体在宿主对单核细胞增生李斯特菌反应中的作用。
