一种强大的 DREADD：揭示功能动力学的结构驱动因素。
A Powerful DREADD: Revealing Structural Drivers of Functional Dynamics.
机构信息
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Neuron. 2016 Jul 20;91(2):213-5. doi: 10.1016/j.neuron.2016.07.011.
In this issue of Neuron, Grayson et al. (2016) report how inhibition of amygdala impacts amygdalocortical and corticocortical functional connectivity. Their study predicts changes in functional brain topology, induced by pharmacologic modulation of neuroanatomical circuits using designer receptors exclusively activated by designer drugs (DREADDs), through virtual lesioning of amygdala in structural brain networks.
在本期《神经元》杂志上，Grayson 等人（2016）报告了杏仁核抑制如何影响杏仁核-皮层和皮层-皮层功能连接。他们的研究通过在结构脑网络中虚拟损毁杏仁核，预测了使用专门被设计药物激活的设计受体（DREADDs）对神经解剖回路进行药物调制后，功能脑拓扑结构的变化。
Zotero 插件