Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Nat Commun. 2024 May 31;15(1):4669. doi: 10.1038/s41467-024-49140-0.
Measures of fMRI resting-state functional connectivity (rs-FC) are an essential tool for basic and clinical investigations of fronto-limbic circuits. Understanding the relationship between rs-FC and the underlying patterns of neural activity in these circuits is therefore vital. Here we introduced inhibitory designer receptors exclusively activated by designer drugs (DREADDs) into the amygdala of two male macaques. We evaluated the causal effect of activating the DREADD receptors on rs-FC and neural activity within circuits connecting amygdala and frontal cortex. Activating the inhibitory DREADD increased rs-FC between amygdala and ventrolateral prefrontal cortex. Neurophysiological recordings revealed that the DREADD-induced increase in fMRI rs-FC was associated with increased local field potential coherency in the alpha band (6.5-14.5 Hz) between amygdala and ventrolateral prefrontal cortex. Thus, our multi-modal approach reveals the specific signature of neuronal activity that underlies rs-FC in fronto-limbic circuits.
静息态功能磁共振成像（rs-FC）测量是研究额-边缘回路的基础和临床研究的重要工具。因此，了解 rs-FC 与这些回路中神经活动的潜在模式之间的关系至关重要。在这里，我们将抑制性 Designer 受体（仅被 Designer 药物激活的受体，DREADD）引入两只雄性猕猴的杏仁核。我们评估了激活 DREADD 受体对连接杏仁核和前额叶皮层的回路中的 rs-FC 和神经活动的因果影响。激活抑制性 DREADD 增加了杏仁核与腹外侧前额叶皮层之间的 rs-FC。神经生理记录显示，DREADD 诱导的 fMRI rs-FC 增加与杏仁核和腹外侧前额叶皮层之间的 alpha 波段（6.5-14.5 Hz）局部场电势相干性增加有关。因此，我们的多模态方法揭示了 rs-FC 在额-边缘回路中神经元活动的特定特征。
