Okada Masahiro, Hiramatsu Daisuke, Okihara Takumi, Matsumoto Takuya
Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.
Dent Mater J. 2016;35(4):651-8. doi: 10.4012/dmj.2015-420.
Application of hydroxyapatite (HAp) nanoparticles to repair damaged enamel has attracted recent attention. In this study, HAp nanoparticles with various morphologies (spherical, short-rod, long-rod and fiber morphologies) were synthesized via chemical precipitation methods without the addition of template molecules, and the adsorption/desorption behaviors of a cationic antibacterial agent, cetylpyridinium chloride (CPC), on the HAp nanoparticles were evaluated. The adsorption of CPC on each HAp nanoparticle showed Langmuir-type adsorption, and the short-rod/long-rod HAp nanoparticles showed thermodynamically more stable adsorption of CPC than that with the spherical/fiber HAp nanoparticles. The desorption rate of CPC from the short-rod/long-rod HAp nanoparticles was slower than that of the spherical/fiber HAp nanoparticles. The HAp nanoparticles with different CPC release profiles presented here have potential applications as nanoparticulate enamel repair agents with antibacterial properties.
羟基磷灰石（HAp）纳米颗粒在修复受损牙釉质方面的应用近来备受关注。在本研究中，通过化学沉淀法在不添加模板分子的情况下合成了具有各种形态（球形、短棒形、长棒形和纤维形）的HAp纳米颗粒，并评估了阳离子抗菌剂十六烷基氯化吡啶（CPC）在HAp纳米颗粒上的吸附/解吸行为。CPC在每种HAp纳米颗粒上均表现出朗缪尔型吸附，且短棒/长棒HAp纳米颗粒对CPC的吸附在热力学上比球形/纤维HAp纳米颗粒更稳定。CPC从短棒/长棒HAp纳米颗粒上的解吸速率比球形/纤维HAp纳米颗粒慢。此处呈现的具有不同CPC释放曲线的HAp纳米颗粒作为具有抗菌性能的纳米牙釉质修复剂具有潜在应用价值。
