Zhu Qiaoqiao, Gao Xin, Li Na, Gu Weiyong, Eismont Frank, Brown Mark D
Dept. of Biomedical Engineering, University of Miami, Coral Gables, FL, United States.
Dept. of Mechanical & Aerospace Engineering, University of Miami, Coral Gables, FL, United States.
J Biomech. 2016 Sep 6;49(13):3079-3084. doi: 10.1016/j.jbiomech.2016.07.012. Epub 2016 Jul 21.
Little quantitative information exists on the kinetics of charged antibiotic penetration into human intervertebral discs (IVD). This information is crucial for determining the dosage to use, timing of administration, and duration of treatment for infected IVDs. The objective of this study was to quantitatively analyze the transport of various charged antibiotics into human lumbar IVDs. Penetration of charged and uncharged antibiotics into a human lumbar disc was analyzed using a 3D finite element model. The valence (z) of the electrical charge of antibiotics varied from z=+2 (positively charged) to z=-2 (negatively charged). An uncharged antibiotic (z=0) was used as a control. Cases with intravenous (IV) administrations of different charged antibiotics were simulated. Our results showed that the electrical charge had great effects on kinetics of an antibiotic penetration into the IVD; with higher concentrations and uptakes for positively charged antibiotics than those for negatively charged ones. This study provides quantitative information on selecting antibiotics for treating intervertebral disc infections.
关于带电抗生素渗透进入人体椎间盘（IVD）的动力学，目前几乎没有定量信息。这些信息对于确定感染性椎间盘疾病的用药剂量、给药时间和治疗持续时间至关重要。本研究的目的是定量分析各种带电抗生素在人体腰椎椎间盘中的转运情况。使用三维有限元模型分析带电和不带电抗生素在人体腰椎椎间盘中的渗透情况。抗生素电荷的价数（z）从z = +2（带正电）到z = -2（带负电）不等。使用一种不带电抗生素（z = 0）作为对照。模拟了静脉注射不同带电抗生素的情况。我们的结果表明，电荷对抗生素渗透进入椎间盘的动力学有很大影响；带正电抗生素的浓度和摄取量高于带负电抗生素。本研究为治疗椎间盘感染选择抗生素提供了定量信息。
