Kato Eisuke, Uenishi Yuta, Inagaki Yosuke, Kurokawa Mihoko, Kawabata Jun
a Laboratory of Food Biochemistry, Division of Applied Bioscience , Graduate School of Agriculture, Hokkaido University , Sapporo , Japan.
b Q'sai Co., Ltd. , Fukuoka , Japan.
Biosci Biotechnol Biochem. 2016 Nov;80(11):2087-2092. doi: 10.1080/09168451.2016.1214533. Epub 2016 Aug 1.
Dipeptidyl peptidase-IV (DPP-IV) is a protease responsible for the degradation of the incretin hormone. A number of DPP-IV inhibitors have been approved for use in the treatment of type 2 diabetes. While these inhibitors are effective for this treatment, methods for the prevention of this disease are also required as diabetes patient numbers are currently increasing rapidly worldwide. We screened the DPP-IV inhibitory activities of edible plant extracts with the intention of using these extracts in a functional food supplement for the prevention of diabetes. Rose (Rosa gallica) bud extract powder was a promising material with high inhibitory activity. In this study, seven ellagitannins were isolated as active compounds through activity-guided fractionations, and their DPP-IV inhibitory activities were measured. Among them, rugosin A and B showed the highest inhibitory activities and rugosin B was shown as the major contributing compound in rose bud extract powder.
二肽基肽酶-IV（DPP-IV）是一种负责降解肠促胰岛素激素的蛋白酶。多种DPP-IV抑制剂已被批准用于治疗2型糖尿病。虽然这些抑制剂对这种治疗有效，但由于目前全球糖尿病患者数量正在迅速增加，因此也需要预防这种疾病的方法。我们筛选了可食用植物提取物的DPP-IV抑制活性，目的是将这些提取物用于预防糖尿病的功能性食品补充剂中。玫瑰（Rosa gallica）花蕾提取物粉末是一种具有高抑制活性的有前景的材料。在本研究中，通过活性导向分级分离法分离出七种鞣花单宁作为活性化合物，并测定了它们的DPP-IV抑制活性。其中，rugosin A和B表现出最高的抑制活性，并且rugosin B被证明是玫瑰花蕾提取物粉末中的主要活性成分。
