Romsaithong S, Tomanakan K, Tangsawad W, Thanaviratananich S
Department of Otolaryngology,Khon Kaen Hospital,Thailand.
Department of Medical Technology,Khon Kaen Hospital,Thailand.
J Laryngol Otol. 2016 Sep;130(9):811-5. doi: 10.1017/S0022215116008598. Epub 2016 Aug 1.
To compare the clinical effectiveness and adverse events for 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in the treatment of otomycosis.
A total of 120 otomycosis patients were randomly assigned to receive either 1 per cent clotrimazole solution (intervention group) or 3 per cent boric acid in 70 per cent alcohol (control group) at the Khon Kaen Hospital ENT out-patient department. Treatment effectiveness was determined based on the otomicroscopic absence of fungus one week after therapy, following a single application of treatment.
After 1 week of treatment, there were data for 109 participants, 54 in the clotrimazole group and 55 in the boric acid group. The absolute difference in cure rates between 1 per cent clotrimazole solution and 3 per cent boric acid in 70 per cent alcohol was 17.9 per cent (95 per cent confidence interval, 2.3 to 33.5; p = 0.028) and the number needed to treat was 6 (95 per cent confidence interval, 3.0 to 43.4). Adverse events for the two agents were comparable.
One per cent clotrimazole solution is more effective than 3 per cent boric acid in 70 per cent alcohol for otomycosis treatment.
比较3%硼酸酒精溶液与1%克霉唑溶液治疗外耳道真菌病的临床疗效及不良事件。
共120例外耳道真菌病患者被随机分配至孔敬医院耳鼻喉科门诊，分别接受1%克霉唑溶液（干预组）或3%硼酸酒精溶液（对照组）治疗。单次治疗后，根据治疗1周后耳镜检查未见真菌确定治疗效果。
治疗1周后，109名参与者有数据，克霉唑组54名，硼酸组55名。1%克霉唑溶液与3%硼酸酒精溶液的治愈率绝对差异为17.9%（95%置信区间，2.3至33.5；p = 0.028），需治疗人数为6（95%置信区间，3.0至43.4）。两种药物的不良事件具有可比性。
在治疗外耳道真菌病方面，1%克霉唑溶液比3%硼酸酒精溶液更有效。
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