克霉唑 1%溶液与硝酸益康唑 1%+曲安奈德 0.1%乳膏治疗真菌性外耳道炎的疗效比较。
Efficacy of Clotrimazole 1% Solution Compared to Econazole Nitrate 1% + Triamcinolone Acetonide 0.1% Cream in Patient with Otomycosis.
机构信息
Dr Md Golam Mostafa, Associate Professor, Department of ENT and Head Neck Surgery, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail:
出版信息
Mymensingh Med J. 2021 Jul;30(3):638-643.
Fungal infection of the ear canal is called Otomycosis. It is more common in hot and humid condition. There are many modalities of treatment or therapeutic agent for treatment of otomycosis. Econazole Nitrate 1% + Triamcinolone Acetonide 0.1% cream is a topical antifungal agent described to be effective in the treatment of otomycosis. This study was performed to compare the efficacy of topical application clotrimazole 1% solution and Econazole Nitrate 1% + Triamcinolone Acetonide 0.1% cream in the treatment of otomycosis. A controlled, randomized and open clinical trial was carried out in ENT department of Mymensingh Medical College Hospital, Mymensingh, Bangladesh from January 2020 to July 2020. Patients diagnosed with fungal otitis externa who were treated with topical antifungals were included in this study. They were randomized into two treatment groups: i) Clotrimazole 1% solution, 2) Econazole Nitrate 1% + Triamcinolone Acetonide 0.1% cream. Patients were microscopically evaluated at two weeks of treatment to determine resolution of disease. Recurrence and complications were recorded. Demographic and clinical variables were collected and analyzed, follow up and final outcomes (absence of infection) were compared between two groups. One hundred & two (102) patients were included, 51 in the clotrimazole 1% solution group and 51 in the Econazole Nitrate 1% + Triamcinolone Acetonide 0.1% cream group. Predominant symptoms are pain, pruritus, aural fullness and hearing loss. Aspergillus organism was isolated most frequently (63.73%). Treatment with clotrimazole 1% solution groups resulted in 88.23% resolution vs. 80.39% resolution with Econazole Nitrate 1% + Triamcinolone Acetonide 0.1% cream at 2 weeks of treatment. Econazole Nitrate 1% + Triamcinolone Acetonide 0.1% cream group demonstrated higher treatment failure 11.76 and 19.60 respectively. Clotrimazole 1% solution is more effective than Econazole Nitrate 1% + Triamcinolone Acetonide 0.1% cream for uncomplicated otomycosis. More study is needed to corroborate our results.
耳道真菌感染被称为耳真菌病。它在炎热潮湿的环境中更为常见。有许多治疗方法或治疗药物可用于治疗耳真菌病。硝酸益康唑 1%+醋酸曲安奈德 0.1%乳膏是一种局部抗真菌药物，据报道对治疗耳真菌病有效。本研究旨在比较硝酸益康唑 1%+醋酸曲安奈德 0.1%乳膏和克霉唑 1%溶液在治疗耳真菌病中的疗效。这是一项在孟加拉国迈门辛医科大学医院耳鼻喉科进行的对照、随机、开放的临床试验，于 2020 年 1 月至 2020 年 7 月进行。纳入接受局部抗真菌药物治疗的真菌性外耳炎患者。他们被随机分为两组：i）克霉唑 1%溶液，ii）硝酸益康唑 1%+醋酸曲安奈德 0.1%乳膏。治疗两周后，对患者进行显微镜评估以确定疾病的缓解情况。记录复发和并发症。收集和分析人口统计学和临床变量，比较两组的随访和最终结果（无感染）。共纳入 102 例（102 例）患者，克霉唑 1%溶液组 51 例，硝酸益康唑 1%+醋酸曲安奈德 0.1%乳膏组 51 例。主要症状是疼痛、瘙痒、耳闷和听力下降。最常分离出的病原体是曲霉菌（63.73%）。克霉唑 1%溶液组治疗 2 周后，缓解率为 88.23%，而硝酸益康唑 1%+醋酸曲安奈德 0.1%乳膏组的缓解率为 80.39%。硝酸益康唑 1%+醋酸曲安奈德 0.1%乳膏组的治疗失败率分别为 11.76%和 19.60%。克霉唑 1%溶液治疗单纯性耳真菌病比硝酸益康唑 1%+醋酸曲安奈德 0.1%乳膏更有效。需要进一步的研究来证实我们的结果。
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