Schug Thaddeus T, Johnson Anne F, Birnbaum Linda S, Colborn Theo, Guillette Louis J, Crews David P, Collins Terry, Soto Ana M, Vom Saal Frederick S, McLachlan John A, Sonnenschein Carlos, Heindel Jerrold J
National Institute of Environmental Health Sciences/National Institutes of Health (T.T.S., J.J.H.), Division of Extramural Research, Research Triangle Park, North Carolina 27560; 2MDB, Inc (A.F.J.), Durham, North Carolina 27713; National Cancer Institute and National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Research Triangle Park, North Carolina 27709; The Endocrine Disruption Exchange (T.Colb.), Paonia, Colorado 81428; Department of Obstetrics and Gynecology (L.J.G.), Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425; Section of Integrative Biology (D.C.), University of Texas at Austin, Austin, Texas 78712; Department of Chemistry (T.Coll.), Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; Department of Anatomy and Cellular Biology (A.M.S., C.S.), Tufts University School of Medicine, Boston, Massachusetts 02155; Division of Biological Sciences and Department (F.S.v.S.),University of Missouri-Columbia, Columbia, Missouri 65211; and Department of Pharmacology (J.A.M.), Tulane University School of Medicine, New Orleans, Louisiana 70118.
Mol Endocrinol. 2016 Aug;30(8):833-47. doi: 10.1210/me.2016-1096. Epub 2016 Jul 19.
Within the past few decades, the concept of endocrine-disrupting chemicals (EDCs) has risen from a position of total obscurity to become a focus of dialogue, debate, and concern among scientists, physicians, regulators, and the public. The emergence and development of this field of study has not always followed a smooth path, and researchers continue to wrestle with questions about the low-dose effects and nonmonotonic dose responses seen with EDCs, their biological mechanisms of action, the true pervasiveness of these chemicals in our environment and in our bodies, and the extent of their effects on human and wildlife health. This review chronicles the development of the unique, multidisciplinary field of endocrine disruption, highlighting what we have learned about the threat of EDCs and lessons that could be relevant to other fields. It also offers perspectives on the future of the field and opportunities to better protect human health.
在过去几十年里，内分泌干扰化学物质（EDCs）的概念从完全不为人知的状态崛起，成为科学家、医生、监管机构和公众之间对话、辩论和关注的焦点。这一研究领域的出现和发展并非总是一帆风顺，研究人员仍在努力解决有关EDCs的低剂量效应和非单调剂量反应、其生物学作用机制、这些化学物质在我们环境和体内的真实普遍程度，以及它们对人类和野生动物健康影响程度的问题。本综述记录了内分泌干扰这一独特的多学科领域的发展，突出了我们对EDCs威胁的了解以及可能与其他领域相关的经验教训。它还对该领域的未来以及更好地保护人类健康的机会提供了观点。
