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Age-dependent modifications of mitochondrial proteins in cerebral cortex and striatum of rat brain.

作者信息

Ragusa N, Turpeenoja L, Magri G, Lähdesmäki P, Giuffrida Stella A M

机构信息

Institute of Biochemistry, Faculty of Medicine, University of Catania, Italy.

出版信息

Neurochem Res. 1989 May;14(5):415-8. doi: 10.1007/BF00964854.

DOI:10.1007/BF00964854
PMID:2747833
Abstract

The protein composition of free mitochondria purified from cerebral cortex and striatum during aging was analyzed by gel electrophoresis. Mitochondria were isolated from cerebral cortex and striatum of 4-, 12-, and 24-month-old rat brain. The percent amount of mitochondrial proteins after gel-electrophoretic separation was determined densitometrically. A significant decrease in the amount of two polypeptides (with molecular weights of 20 and 16 kDa, respectively) in both brain regions during aging was found. The decrease was higher in the striatum indicating a greater vulnerability of this brain area to the aging process. The age-dependent modifications of mitochondrial proteins observed may play an important role in several mitochondrial functions, such as energy transduction and transport processes as well as in structural changes occurring with age, causing altered membrane permeability and fluidity.

摘要

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