少突胶质细胞消融作为研究脱髓鞘疾病的一种工具。

Pajoohesh-Ganji Ahdeah, Miller Robert H

Department of Anatomy and Regenerative Biology, The George Washington University, School of Medicine and Health Sciences, Washington DC, USA.

Neural Regen Res. 2016 Jun;11(6):886-9. doi: 10.4103/1673-5374.184451.

Multiple sclerosis (MS) is an autoimmune mediated neurodegenerative disease characterized by demyelination and oligodendrocyte (OL) loss in the central nervous system and accompanied by local inflammation and infiltration of peripheral immune cells. Although many risk factors and symptoms have been identified in MS, the pathology is complicated and the cause remains unknown. It is also unclear whether OL apoptosis precedes the inflammation or whether the local inflammation is the cause of OL death and demyelination. This review briefly discusses several models that have been developed to specifically ablate oligodendrocytes in an effort to separate the effects of demyelination from inflammation.

多发性硬化症（MS）是一种自身免疫介导的神经退行性疾病，其特征是中枢神经系统发生脱髓鞘和少突胶质细胞（OL）丢失，并伴有局部炎症和外周免疫细胞浸润。尽管在MS中已发现许多危险因素和症状，但其病理过程复杂，病因仍不明。此外，尚不清楚OL凋亡是先于炎症发生，还是局部炎症是OL死亡和脱髓鞘的原因。本综述简要讨论了几种专门用于消融少突胶质细胞的模型，以试图区分脱髓鞘和炎症的影响。