Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030; email:
Center for Theoretical Biological Physics, Rice University, Houston, Texas 77005.
Annu Rev Virol. 2016 Sep 29;3(1):453-472. doi: 10.1146/annurev-virology-110615-042127. Epub 2016 Jul 22.
Studies over more than half a century have resulted in what some consider a complete narrative for the life cycle of bacteriophage λ. However, this narrative is only complete within the limited resolution offered by the traditional genetic and biochemical approaches that were used to create it. A recent series of studies performed at the single-cell and single-phage levels has revealed a wealth of previously unknown features. By pointing to many open questions, these new studies highlight the limitations of our current understanding of λ, but they also initiate the process of forming a more detailed and quantitative narrative for the system.
半个多世纪的研究成果为噬菌体 λ 的生命周期提供了一些人认为完整的描述。然而，这个描述只是在传统的遗传和生化方法所提供的有限分辨率内完整的，这些方法被用来创建它。最近在单细胞和单噬菌体水平上进行的一系列研究揭示了大量以前未知的特征。这些新的研究通过指出许多悬而未决的问题，突出了我们目前对 λ 理解的局限性，但它们也启动了为该系统形成更详细和定量描述的过程。
