Kötzschke H, Krämer R, Haufe M
Stomatol DDR. 1978 Feb;28(2):97-102.
The changes occurring in the oral mucosa, gingivae and periodontium of guinea pigs fed a vitamin C-deficient diet were determined by means of histological comparison with animals on a normal diet. The following results were obtained from the scorbutic guinea pigs: --detachment of the horny layer from the underlying epithelium, --bullous cells in the spinose and the granular layer, --formation of periodontal pockets, --reduction in number and disorientation of collagenous fibres of the periodontium associated with loosening of the molars.
通过与正常饮食的豚鼠进行组织学比较，确定了喂食缺乏维生素C饮食的豚鼠口腔黏膜、牙龈和牙周组织发生的变化。从患坏血病的豚鼠身上获得了以下结果：——角质层与下层上皮分离，——棘层和颗粒层出现水疱样细胞，——形成牙周袋，——与臼齿松动相关的牙周胶原纤维数量减少且排列紊乱。
