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膝状神经节肿瘤:临床表现与手术结果

Geniculate Ganglion Tumors: Clinical Presentation and Surgical Results.

作者信息

Lahlou Ghizlene, Nguyen Yann, Russo Francesca Yoshie, Ferrary Evelyne, Sterkers Olivier, Bernardeschi Daniele

机构信息

AP-HP, Pitie-Salpetriere Hospital, Otology, Auditory Implants and Skull Base Surgery Department, Paris, France.

Sorbonne Universités, UPMC Univ Paris 06, Paris, France.

出版信息

Otolaryngol Head Neck Surg. 2016 Nov;155(5):850-855. doi: 10.1177/0194599816661482. Epub 2016 Aug 2.

DOI:10.1177/0194599816661482
PMID:27484229
Abstract

OBJECTIVE

Facial nerve tumors are rare lesions mostly located in the geniculate ganglion. This study aims to compare those tumors limited to the geniculate ganglion in terms of clinical features and postoperative outcomes.

STUDY DESIGN

Case series with chart review.

SETTINGS

University tertiary reference center.

SUBJECTS AND METHODS

Medical charts were reviewed for 17 patients who had surgery for geniculate ganglion tumor removal (10 hemangiomas, 6 schwannomas, 1 meningioma). Hemangiomas and schwannomas were compared for preoperative facial nerve function, hearing, tumor size, and postoperative outcomes.

RESULTS

Facial palsy was observed in all cases. Regarding the preoperative facial nerve function, severe facial palsy (House-Brackmann grades V and VI) was present in 70% of cases for hemangiomas and for no case of schwannoma (P = .01), although hemangiomas were significantly smaller tumors (P = .01). Hearing loss was observed in 4 cases (23.5%) and was related to tumor volume (P < .0001). A complete excision was achieved in all cases, and a facial nerve graft was performed immediately after interruption in 16 patients (94%). Postoperative facial nerve function was improved or stabilized in 94% of cases. A preoperative House-Brackman grade VI was shown as a negative factor for postoperative facial nerve function.

CONCLUSIONS

Differences in clinical presentations could help in establishing the good therapeutic option depending on the tumor type. Surgery, when indicated, is safe and effective, and postoperative outcomes are not related to tumor type.

摘要

目的

面神经肿瘤是罕见病变,大多位于膝状神经节。本研究旨在比较局限于膝状神经节的这些肿瘤的临床特征和术后结果。

研究设计

病例系列并进行图表回顾。

研究地点

大学三级转诊中心。

研究对象和方法

回顾了17例行膝状神经节肿瘤切除术患者的病历(10例血管瘤、6例神经鞘瘤、1例脑膜瘤)。比较血管瘤和神经鞘瘤的术前面神经功能、听力、肿瘤大小及术后结果。

结果

所有病例均观察到面瘫。关于术前面神经功能,70%的血管瘤病例存在严重面瘫(House-Brackmann分级V级和VI级),而神经鞘瘤病例无一例如此(P = 0.01),尽管血管瘤的肿瘤明显较小(P = 0.01)。4例(23.5%)出现听力损失,且与肿瘤体积有关(P < 0.0001)。所有病例均实现了完全切除,16例患者(94%)在面神经中断后立即进行了面神经移植。94%的病例术后面神经功能得到改善或稳定。术前House-Brackman VI级是术后面神经功能的负面因素。

结论

临床表现的差异有助于根据肿瘤类型确定良好的治疗方案。手术在有指征时安全有效,术后结果与肿瘤类型无关。

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