补充ω-3脂肪酸对多囊卵巢综合征女性胰岛素抵抗的影响：随机对照试验的Meta分析

Effect of omega-3 fatty acids supplementation on insulin resistance in women with polycystic ovary syndrome: Meta-analysis of randomized controlled trials.

作者信息

Sadeghi Alirez, Djafarian Kurosh, Mohammadi Hamed, Shab-Bidar Sakineh

机构信息

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

出版信息

Diabetes Metab Syndr. 2017 Apr-Jun;11(2):157-162. doi: 10.1016/j.dsx.2016.06.025. Epub 2016 Jul 4.

DOI:10.1016/j.dsx.2016.06.025

PMID:27484441

Abstract

BACKGROUND

Several studies have shown that omega-3 polyunsaturated fatty acids (PUFA) may improve insulin resistance in various diseases. However, the possible effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on insulin resistance in PCOS still remains unclear. We evaluated the effect of omega-3 PUFA supplementation on insulin resistance in women with PCOS in a meta-analysis.

METHODS

Literature searches of MEDLINE, PubMed Central and EMBASE for publications in English were conducted up to December 2015. We included all randomized controlled trials (RCTs) that investigated effects of omega-3 fatty acids supplements on insulin resistance in women with PCOS. Results are summarized as mean differences (MD) with 95% confidence intervals (CI). Effect sizes of eligible studies were pooled using random-effects models (the DerSimonian-Laird estimator). We assessed the potential sources of heterogeneity using the standard χ2 test.

RESULTS

Of 1202 papers, three RCTs were eligible for inclusion which involved 72 cases and 73 controls. The dose range for omega3 supplement was 1.2g to 3.6g and the duration of follow-up was from 6 to 8 weeks. There was no significant effect of omega-3 fatty acids supplements compared to placebo on insulin resistance (MD: 6.18; CI; -3.347, 15.382; p=0.208) and HOMA -IR (MD: 0.276; 95% CI=-1.428, 1.981; p=0.751) in women with PCOS.

CONCLUSION

The results provide an evidence that supplementation with omega-3 fatty acids may not have a beneficial effect on improving insulin resistance in women with PCOS.

摘要

背景

多项研究表明，ω-3多不饱和脂肪酸（PUFA）可能改善多种疾病中的胰岛素抵抗。然而，补充二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）对多囊卵巢综合征（PCOS）患者胰岛素抵抗的潜在影响仍不明确。我们通过一项荟萃分析评估了补充ω-3多不饱和脂肪酸对PCOS女性胰岛素抵抗的影响。

方法

截至2015年12月，我们对MEDLINE、PubMed Central和EMBASE进行了英文文献检索。我们纳入了所有研究ω-3脂肪酸补充剂对PCOS女性胰岛素抵抗影响的随机对照试验（RCT）。结果以平均差（MD）及95%置信区间（CI）进行总结。采用随机效应模型（DerSimonian-Laird估计量）汇总符合条件研究的效应量。我们使用标准χ²检验评估异质性的潜在来源。

结果

在1202篇论文中，三项RCT符合纳入标准，共涉及72例病例和73例对照。ω-3补充剂的剂量范围为1.2克至3.6克，随访时间为6至8周。与安慰剂相比，ω-3脂肪酸补充剂对PCOS女性的胰岛素抵抗（MD：6.18；CI：-3.347，15.382；p = 0.208）和稳态模型评估的胰岛素抵抗指数（HOMA-IR）（MD：0.276；95%CI = -1.428，1.981；p = 0.751）无显著影响。