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优化的营养组合治疗 PCOS 特征的疗效：一项计算机模拟评估。

Efficacy of optimal nutraceutical combination in treating PCOS characteristics: an in-silico assessment.

机构信息

MetFlux Research Pvt Ltd, Mumbai, India.

Dr Reddy's Laboratories Pvt Ltd, Hyderabad, India.

出版信息

BMC Endocr Disord. 2024 Mar 29;24(1):44. doi: 10.1186/s12902-024-01571-y.

DOI:10.1186/s12902-024-01571-y
PMID:38549084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10979615/
Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is a serious health condition affecting women of reproductive age. High prevalence of PCOS and associated metabolic complications needs effective treatment and management. This study evaluated the efficacy of optimal nutraceutical combinations in improving PCOS characteristics using system biology-based mathematical modelling and simulation.

METHODS

A shortlisting of eight potent nutraceuticals was carried out with literature search. Menstrual cycle model was used to perform simulations on an in-silico population of 2000 individuals to test individual and combined effects of shortlisted nutraceuticals on five PCOS characteristics [oligomenorrhea, anovulation, hirsutism, infertility, and polycystic ovarian morphology (PCOM)] for a duration of 6 months. Efficacy was tested across lean and obese phenotypes and age groups.

RESULTS

Individual assessment of nutraceuticals revealed seven most potent compounds. Myo-inositol among them was observed to be the most effective in alleviating the PCOS characteristics. The in-silico population analysis showed that the combination of melatonin and ALA along with myo-inositol was efficacious in restoring the hormonal balance across age-groups and Body Mass Index (BMI) categories.

CONCLUSION

Supplementation with the combination of myo-inositol, melatonin, and ALA demonstrated potential in managing PCOS symptoms in our in-silico analysis of a heterogeneous population, including lean and obese phenotypes across various severities and age groups, over a 6-month period. Future clinical studies are recommended to validate these findings.

摘要

背景

多囊卵巢综合征（PCOS）是一种严重影响育龄期妇女健康的疾病。PCOS 的高患病率及其相关代谢并发症需要有效的治疗和管理。本研究采用基于系统生物学的数学建模和模拟方法，评估了最佳营养组合改善 PCOS 特征的疗效。

方法

通过文献检索对 8 种有效的营养物进行了筛选。使用月经周期模型对 2000 名个体的虚拟人群进行模拟，以测试所筛选的营养物对 5 种 PCOS 特征（稀发排卵、无排卵、多毛症、不孕和多囊卵巢形态（PCOM））的单独和联合作用，为期 6 个月。在肥胖和消瘦表型以及不同年龄组中对疗效进行了测试。

结果

对营养物的单独评估显示出 7 种最有效的化合物。其中肌醇被观察到在缓解 PCOS 特征方面最有效。虚拟人群分析表明，褪黑素和 ALA 与肌醇的联合补充在各年龄段和体重指数（BMI）类别中均能有效恢复激素平衡。

结论

在对包括消瘦和肥胖表型以及不同严重程度和年龄组在内的异质人群进行的虚拟分析中，补充肌醇、褪黑素和 ALA 的组合显示出在 6 个月的时间内有潜力改善 PCOS 症状。建议进行未来的临床研究来验证这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/c4c3d2878121/12902_2024_1571_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/7c9869ddf4c0/12902_2024_1571_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/7e0b6e2ffb59/12902_2024_1571_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/b85985481d4c/12902_2024_1571_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/952544505ce7/12902_2024_1571_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/eed56b19c2c5/12902_2024_1571_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/c4c3d2878121/12902_2024_1571_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/7c9869ddf4c0/12902_2024_1571_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/7e0b6e2ffb59/12902_2024_1571_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/b85985481d4c/12902_2024_1571_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/952544505ce7/12902_2024_1571_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/eed56b19c2c5/12902_2024_1571_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd5e/10979615/c4c3d2878121/12902_2024_1571_Fig6_HTML.jpg

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