Sivaraj Kishor K, Adams Ralf H
Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine, Münster D-48149, Germany.
Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine, Münster D-48149, Germany
Development. 2016 Aug 1;143(15):2706-15. doi: 10.1242/dev.136861.
In addition to their conventional role as a conduit system for gases, nutrients, waste products or cells, blood vessels in the skeletal system play active roles in controlling multiple aspects of bone formation and provide niches for hematopoietic stem cells that reside within the bone marrow. In addition, recent studies have highlighted roles for blood vessels during bone healing. Here, we provide an overview of the architecture of the bone vasculature and discuss how blood vessels form within bone, how their formation is modulated, and how they function during development and fracture repair.
除了作为气体、营养物质、代谢产物或细胞的输送系统这一传统作用外，骨骼系统中的血管在控制骨形成的多个方面发挥着积极作用，并为骨髓中的造血干细胞提供微环境。此外，最近的研究强调了血管在骨愈合过程中的作用。在这里，我们概述了骨血管系统的结构，并讨论了血管在骨内如何形成、其形成如何被调节，以及它们在发育和骨折修复过程中如何发挥作用。
