Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine, D-48149 Münster, Germany.
Cold Spring Harb Perspect Med. 2018 Jul 2;8(7):a031559. doi: 10.1101/cshperspect.a031559.
Blood vessels are essential for the distribution of oxygen, nutrients, and immune cells, as well as the removal of waste products. In addition to this conventional role as a versatile conduit system, the endothelial cells forming the innermost layer of the vessel wall also possess important signaling capabilities and can control growth, patterning, homeostasis, and regeneration of the surrounding organ. In the skeletal system, blood vessels regulate developmental and regenerative bone formation as well as hematopoiesis by providing vascular niches for hematopoietic stem cells. Here we provide an overview of blood vessel architecture, growth and properties in the healthy, aging, and diseased skeletal system.
血管对于氧气、营养物质和免疫细胞的分布以及废物的清除至关重要。除了作为一种通用的输送系统的传统作用外，形成血管壁内层的内皮细胞还具有重要的信号传递能力，可以控制周围器官的生长、形态发生、内稳态和再生。在骨骼系统中，血管通过为造血干细胞提供血管龛来调节发育和再生性骨形成以及造血。在这里，我们概述了健康、衰老和患病骨骼系统中血管的结构、生长和特性。
