Zeliger Harold I, Lipinski Boguslaw
Zeliger Research and Consulting, Cape Elizabeth, Maine, USA.
Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts, USA.
Interdiscip Toxicol. 2015 Mar;8(1):15-21. doi: 10.1515/intox-2015-0003.
The onset of human degenerative diseases in humans, including type 2 diabetes, cardiovascular disease, neurological disorders, neurodevelopmental disease and neurodegenerative disease has been shown to be related to exposures to persistent organic pollutants, including polychlorinated biphenyls, chlorinated pesticides, polybrominated diphenyl ethers and others, as well as to polynuclear aromatic hydrocarbons, phthalates, bisphenol-A and other aromatic lipophilic species. The onset of these diseases has also been related to exposures to transition metal ions. A physiochemical mechanism for the onset of degenerative environmental disease dependent upon exposure to a combination of lipophilic aromatic hydrocarbons and transition metal ions is proposed here. The findings reported here also, for the first time, explain why aromatic hydrocarbons exhibit greater toxicity than aliphatic hydrocarbons of equal carbon numbers.
人类退行性疾病的发生，包括2型糖尿病、心血管疾病、神经紊乱、神经发育疾病和神经退行性疾病，已被证明与接触持久性有机污染物有关，这些污染物包括多氯联苯、氯化农药、多溴二苯醚等，以及与多核芳烃、邻苯二甲酸盐、双酚A和其他芳香亲脂性物质有关。这些疾病的发生也与接触过渡金属离子有关。本文提出了一种依赖于接触亲脂性芳烃和过渡金属离子组合的退行性环境疾病发病的物理化学机制。本文报道的研究结果还首次解释了为什么芳烃比同等碳原子数的脂肪烃具有更大的毒性。
