Zeliger Harold I
Zeliger Research & Consulting, Cape Elizabeth, ME 04107, USA.
Interdiscip Toxicol. 2016 Jun;9(2):39-54. doi: 10.1515/intox-2016-0006. Epub 2017 May 17.
Virtually all human disease is induced by oxidative stress. Oxidative stress, which is caused by toxic environmental exposure, the presence of disease, lifestyle choices, stress, chronic inflammation or combinations of these, is responsible for most disease. Oxidative stress from all sources is additive and it is the total oxidative stress from all sources that induces the onset of most disease. Oxidative stress leads to lipid peroxidation, which in turn produces Malondialdehyde. Serum malondialdehyde level is an additive parameter resulting from all sources of oxidative stress and, therefore, is a reliable indicator of total oxidative stress which can be used to predict the onset of disease in clinically asymptomatic individuals and to suggest the need for treatment that can prevent much human disease.
几乎所有人类疾病都是由氧化应激诱导的。氧化应激是由有毒的环境暴露、疾病的存在、生活方式的选择、压力、慢性炎症或这些因素的组合引起的，它是大多数疾病的病因。来自所有来源的氧化应激是累加的，正是来自所有来源的总氧化应激诱发了大多数疾病的发作。氧化应激会导致脂质过氧化，进而产生丙二醛。血清丙二醛水平是所有氧化应激来源产生的一个累加参数，因此，它是总氧化应激的可靠指标，可用于预测临床无症状个体疾病的发作，并提示是否需要进行能够预防许多人类疾病的治疗。
