Chemistry Research Laboratory, Department of Chemistry, University of Oxford , Oxford OX1 3TA, U.K.
Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford , Oxford OX1 3QU, U.K.
Org Lett. 2016 Aug 19;18(16):4112-5. doi: 10.1021/acs.orglett.6b02041. Epub 2016 Aug 3.
Ease of separation of petrol-soluble acetonides derived from the triacetonide of methyl glucoheptonate allows scalable syntheses of rare sugars containing the l-gluco or d-gulo structural motif with any oxidation level at the C6 or C1 position of the hexose, usually without chromatography: meso-d-glycero-d-guloheptitol available in two steps is an ideal entry point for the study of the biotechnological production of heptoses.
从甲基葡庚酮三缩酮衍生出的油溶性丙酮化物易于分离，这使得具有 l-葡糖或 d-古洛结构基序的稀有糖的可扩展合成成为可能，其中六碳糖的 C6 或 C1 位的任何氧化水平都可以实现，通常无需进行色谱分离：两步法可得的 meso-d-甘油-d-古洛庚糖醇是研究庚糖生物合成生产的理想切入点。
