通过七碳糖从 d-葡萄糖中得到 d-艾杜糖醛酸、d-艾杜糖酸和 d-艾杜糖酸。
d-Idose, d-Iduronic Acid, and d-Idonic Acid from d-Glucose via Seven-Carbon Sugars.
机构信息
Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.
Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
出版信息
Molecules. 2019 Oct 18;24(20):3758. doi: 10.3390/molecules24203758.
A practical synthesis of the very rare sugar d-idose and the stable building blocks for d-idose, d-iduronic, and d-idonic acids from -heptonic acid requires only isopropylidene protection, Shing silica gel-supported periodate cleavage of the C6-C7 bond of the heptonic acid, and selective reduction of C1 and/or C6. d-Idose is the most unstable of all the aldohexoses and a stable precursor which be stored and then converted under very mild conditions into d-idose is easily prepared.
从 - 庚酸出发，通过异丙叉保护、Shing 硅胶负载高碘酸盐选择性断裂 C6-C7 键以及选择性还原 C1 和/或 C6，即可实现非常罕见的糖 d-idose 及其稳定的构筑块 d-iduronic 和 d-idonic 酸的实际合成。d-idose 是所有 aldose 中最不稳定的，很容易制备出一种稳定的前体，可以储存起来，然后在非常温和的条件下转化为 d-idose。
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