Fantinati Marcelo Silva, Mendonça Diego Eterno Oliveira, Fantinati Adriana Márcia Monteiro, Santos Bruno Flamarion Dos, Reis Juliana Cristina Oliveira, Afonso Cristina Lopes, Vinaud Marina Clare, Lino Ruy de Souza
PhD, Full Professor, Superior School of Physical Education and Physical Therapy of Goias State (ESEFFEGO), Universidade Estadual de Goiás (UEG), Goias-GO, Brazil. Intellectual, scientific, conception and design of the study;manuscript writing.
Fellow Master degree, Postgraduation Program in Host-Parasite Relationship, Tropical Pathology and Public Health Institute, UFG, Goias-GO, Brazil. Acquisition of data.
Acta Cir Bras. 2016 Jul;31(7):463-71. doi: 10.1590/S0102-865020160070000006.
To evaluate the effects of low intensity ultrasound on the healing process of third degree burn wounds in experimentally induced diabetic Wistar rats.
One hundred rats were divided into: control group; non-diabetic treated group; diabetic control group; diabetic treated group. The therapy was performed with a 3MHz ultrasound application, pulsed emission at 100Hz frequency, modulated at 20% with a dosage of 0.5W/cm2 during three minutes throughout 30 days. The surgical debridement of the wound was performed once at day 2. The wounds were morphometrically, macroscopically and microscopically evaluated at 3, 7, 14, 21 and 30 days.
The wound contraction and collagen quantification were higher in all treated groups. Macroscopically, necrosis was higher in the diabetic control group. Granulation tissue was higher in treated groups during the proliferative and remodeling phase. Microscopically, there were greater mononuclear inflammatory infiltration, angiogenesis and fibroblast quantification in treated groups during the proliferative and remodeling phases.
therapeutic ultrasound is beneficial in the inflammatory and proliferative phases of the healing process because it controlled the necrotic tissue, increased the granulation tissue and wound contraction. However in the remodeling phase it is not beneficial because of the continued angiogenesis and a mononuclear inflammatory infiltration.
评估低强度超声对实验性诱导糖尿病的Wistar大鼠三度烧伤创面愈合过程的影响。
将100只大鼠分为：对照组；非糖尿病治疗组；糖尿病对照组；糖尿病治疗组。采用3MHz超声进行治疗，频率为100Hz的脉冲发射，调制率为20%，剂量为0.5W/cm²，持续3分钟，共30天。在第2天对创面进行一次手术清创。在第3、7、14、21和30天对创面进行形态学、宏观和微观评估。
所有治疗组的创面收缩和胶原蛋白定量均较高。宏观上，糖尿病对照组的坏死程度较高。在增殖和重塑阶段，治疗组的肉芽组织较多。微观上，在增殖和重塑阶段，治疗组有更多的单核炎性浸润、血管生成和成纤维细胞定量。
治疗性超声在愈合过程的炎症和增殖阶段是有益的，因为它控制了坏死组织，增加了肉芽组织和创面收缩。然而，在重塑阶段它是无益的，因为持续的血管生成和单核炎性浸润。
