Universidade Federal de Goiás - Tropical Pathology and Public Health Institute - Goiânia (GO) - Brazil.
Instituto Master de Ensino Presidente Antônio Carlos - Medicine School - Itumbiara (GO) - Brazil.
Acta Cir Bras. 2023 Oct 23;38:e385323. doi: 10.1590/acb385323. eCollection 2023.
The angiogenic, osteogenic and anti-inflammatory activity of latex of Hancornia speciosa has been evidenced and indicates pharmacological potential with great applicability in the health area, especially in the wound healing process. The present work aimed to compare the effects of the H. speciosa macroporous latex biomembrane with saline on wound healing.
Forty-three Wistar rats were submitted to excisional wound induction procedure and divided into groups according to treatment: saline (G1), and macroporous biomembrane (G2). The animals were euthanized at three, seven, 14, and 21 days after injury induction (DAI), and three animals were used for the debridement test. Morphometric, macroscopic, and microscopic analyses of general pathological processes were performed.
The macroporous biomembrane minimized necrosis and inflammation during the inflammatory and proliferative phases of the healing process, confirmed by the lower intensity of the crust and the debridement effect. In addition, the wounds treated with the macroporous biomembrane presented greater contraction rates in all the experimental periods analyzed.
The macroporous biomembrane presents angiogenic, anti-inflammatory and debridement effects, contributing to the healing process, and can be considered a potentially promising new biomaterial to be used as a dressing.
已证实牛奶树乳胶具有血管生成、成骨和抗炎活性，这表明其具有很大的应用潜力，可应用于医疗领域，特别是在伤口愈合过程中。本研究旨在比较牛奶树大孔乳胶生物膜与生理盐水对伤口愈合的影响。
将 43 只 Wistar 大鼠进行切口诱导实验，并根据治疗方法分为两组：生理盐水（G1）和大孔生物膜（G2）。在损伤诱导后 3、7、14 和 21 天（DAI）处死动物，并对 3 只动物进行清创试验。对一般病理过程的形态计量学、宏观和微观分析。
大孔生物膜在伤口愈合的炎症和增殖阶段最小化了坏死和炎症，这可以通过较低的结痂强度和清创效果得到证实。此外，在所有实验分析的时期中，用大孔生物膜处理的伤口都具有更高的收缩率。
大孔生物膜具有血管生成、抗炎和清创作用，有助于伤口愈合，可以被认为是一种有前途的新型生物材料，可作为敷料使用。
