Chen I S, Chen J J, Duh C Y, Tsai I L, Chang C T
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
Planta Med. 1997 Apr;63(2):154-7. doi: 10.1055/s-2006-957634.
Two new aporphine alkaloids, (+)-N-hydroxyhernangerine (1) and N-formyldehydroovigerine (2) as minor bases, along with four known aporphines, (+)-magnoflorine, (+)-hernovine, (+)-N-methylhernovine, and (+)-laurotetanine, two known isoquinolones, thalifoline and northalifoline, and one benzylisoquinoline, (+)-reticuline, have been additionally isolated from the trunk bark of Hernandia nymphaeifolia. The structures of these compounds were elucidated by spectroscopic evidence. Six of the isolated compounds show significant cytotoxic activities (ED50 values < 1 microgram/ml) against P-388, KB16, A549, or HT-29 cell lines.
从莲叶桐的树干树皮中又分离出了两种新的阿朴啡生物碱，即（+）-N-羟基hernangerine（1）和N-甲酰基脱氢卵叶木兰碱（2）作为次要碱，以及四种已知的阿朴啡，（+）-木兰碱、（+）-hernovenine、（+）-N-甲基hernovenine和（+）-劳罗替宁，两种已知的异喹诺酮，thalifoline和northalifoline，以及一种苄基异喹啉，（+）-网叶番荔枝碱。这些化合物的结构通过光谱证据得以阐明。其中六种分离出的化合物对P-388、KB16、A549或HT-29细胞系表现出显著的细胞毒性活性（半数有效剂量值<1微克/毫升）。
