运动作为基因治疗：BDNF 和 DNA 损伤修复。
Exercise as Gene Therapy: BDNF and DNA Damage Repair.
机构信息
From the *Department of Ophthalmology, Emory University School of Medicine, Atlanta; and †Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, GA.
出版信息
Asia Pac J Ophthalmol (Phila). 2016 Jul-Aug;5(4):309-11. doi: 10.1097/APO.0000000000000226.
Abstract
DNA damage is a common feature of neurodegenerative illnesses, and the ability to repair DNA strand breaks and lesions is crucial for neuronal survival, reported by Jeppesen et al (Prog Neurobiol. 2011;94:166-200) and Shiwaku et al (Curr Mol Med. 2015;15:119-128). Interventions aimed at repairing these lesions, therefore, could be useful for preventing or delaying the progression of disease. One potential strategy for promoting DNA damage repair (DDR) is exercise. Although the role of exercise in DDR is not understood, there is increasing evidence that simple physical activity may impact clinical outcomes for neurodegeneration. Here, we discuss what is currently known about the molecular mechanisms of brain-derived neurotrophic factor and how these mechanisms might influence the DDR process.
摘要
DNA 损伤是神经退行性疾病的一个常见特征，修复 DNA 链断裂和损伤的能力对神经元的存活至关重要，这是由 Jeppesen 等人（Prog Neurobiol. 2011;94:166-200）和 Shiwaku 等人（Curr Mol Med. 2015;15:119-128）报道的。因此，旨在修复这些损伤的干预措施可能有助于预防或延缓疾病的进展。促进 DNA 损伤修复 (DDR) 的一种潜在策略是运动。尽管运动在 DDR 中的作用尚不清楚，但越来越多的证据表明，简单的体育活动可能会影响神经退行性疾病的临床结果。在这里，我们讨论了目前已知的脑源性神经营养因子的分子机制，以及这些机制如何影响 DDR 过程。
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