Vilela Carla, Figueiredo Ana R P, Silvestre Armando J D, Freire Carmen S R
a CICECO - Aveiro Institute of Materials, Department of Chemistry , University of Aveiro , Aveiro , Portugal.
Expert Opin Drug Deliv. 2017 Feb;14(2):189-200. doi: 10.1080/17425247.2016.1214568. Epub 2016 Aug 5.
The design of efficient therapeutic delivery devices has become a tremendously active area of research with a strong contribution from the layer-by-layer (LbL) technology. The application of this simple yet firmly established technique for the design of drug reservoirs originates a multitude of multilayered systems of tailored architecture and with a high level of control of drug administration. Areas covered: This review will focus on the most recent and original research on LbL assemblies based on biopolymers including polysaccharides, polypeptides and proteins, with potential use in drug delivery. Herein, drug reservoirs consisting of multilayered planar films and capsules will be examined with emphasis on the ones benefiting from the non-cytotoxic and biocompatible nature of biopolymers, which are suitable to load, protect and release a high payload of toxic and fragile drugs. Expert opinion: The combination of biopolymers with LbL technology has undergone extensive research, still, there is a multitude of R&D opportunities for the design of smart drug delivery systems with distinct multilayered morphologies, low immunological response, non-invasive drug release devices, as well as the design of theranostic systems combining diagnostics and therapeutic features. Further developments in terms of scaling towards mass production in the pharmaceutical industry are expected in the long-term.
高效治疗给药装置的设计已成为一个极为活跃的研究领域，层层（LbL）技术在其中发挥了重要作用。这种简单却成熟的技术应用于药物储库的设计，催生了众多具有定制结构且能高度控制药物给药的多层系统。涵盖领域：本综述将聚焦于基于生物聚合物（包括多糖、多肽和蛋白质）的层层组装体的最新原创研究，这些组装体在药物递送方面具有潜在应用价值。在此，将对由多层平面膜和胶囊组成的药物储库进行研究，重点关注那些受益于生物聚合物非细胞毒性和生物相容性的储库，它们适合装载、保护和释放高负载量的有毒且脆弱的药物。专家观点：生物聚合物与层层技术的结合已历经广泛研究，然而，在设计具有独特多层形态、低免疫反应、非侵入性药物释放装置的智能药物递送系统，以及结合诊断和治疗功能的治疗诊断系统方面，仍有大量研发机会。从长远来看，预计在制药行业向大规模生产的规模化发展方面会有进一步进展。
