Department of Chemical and Biomolecular Engineering, The University of Melbourne, Centre for Nanoscience and Nanotechnology, Parkville, Victoria 3010, Australia.
Small. 2010 Sep 6;6(17):1836-52. doi: 10.1002/smll.201000379.
Polymeric materials formed via layer-by-layer (LbL) assembly have promise for use as drug delivery vehicles. These multilayered materials, both as capsules and thin fi lms, can encapsulate a high payload of toxic or sensitive drugs, and can be readily engineered and functionalized with specific properties. This review highlights important and recent studies that advance the use of LbL-assembled materials as therapeutic devices. It also seeks to identify areas that require additional investigation for future development of the field. A variety of drug-loading methods and delivery routes are discussed. The biological barriers to successful delivery are identified, and possible solutions to these problems are discussed. Finally, state-of-the-art degradation and cargo release mechanisms are also presented.
通过层层组装形成的聚合材料有望用作药物输送载体。这些多层材料，无论是胶囊还是薄膜，都可以封装高负载的有毒或敏感药物，并且可以通过特定的性质进行易于设计和功能化。本综述重点介绍了推进使用 LbL 组装材料作为治疗设备的重要和最新研究。它还试图确定该领域未来发展需要进一步研究的领域。讨论了各种药物加载方法和输送途径。确定了成功输送的生物屏障，并讨论了这些问题的可能解决方案。最后，还介绍了最先进的降解和货物释放机制。
