Zhang Renjiao, Liu Hongwei, Bai Huai, Zhang Yujin, Liu Qingqing, Guan Linbo, Fan Ping
Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, China.
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Clin Endocrinol (Oxf). 2017 Jan;86(1):88-96. doi: 10.1111/cen.13171. Epub 2016 Sep 5.
To determine oxidative stress status and its association with clinical and metabolic parameters in Chinese women with different clinical phenotypes of polycystic ovary syndrome (PCOS).
A cross-sectional study.
A total of 544 patients with PCOS and 468 control women were included.
The total oxidant status (TOS) was determined using a microplate colorimetric method. Total antioxidant capacity (T-AOC), oxidative stress index (OSI, the ratios of TOS to T-AOC) and clinical, hormonal and metabolic parameters were also analysed.
TOS and OSI were significantly higher in each of the four PCOS phenotypes based on the Rotterdam criteria than in the control women and higher in patients with hyperandrogenism (HA) than in those without HA (P < 0·05). TOS, T-AOC and OSI were higher in lean patients than in lean controls (P < 0·05). These values, except OSI, were also higher in overweight/obese patients than in lean patients, and lean or overweight/obese controls (P < 0·05). Multivariate regression analysis demonstrated that apolipoprotein (apo)A1, the Ferriman-Gallwey score, triglyceride (TG), oestradiol (E ), high-density lipoprotein cholesterol (HDL-C) and 2-h glucose levels were the main predictors of TOS; the Ferriman-Gallwey score, E , apoA1, TG and HDL-C levels were the main predictors of OSI.
Patients with PCOS with HA have higher oxidative stress levels compared with those without HA. The increased oxidative stress in PCOS is related to HA status, increased plasma glucose, TG, HDL-C and E levels, decreased apoA1 concentrations and a relative shortage of antioxidant capacity.
确定不同临床表型的中国多囊卵巢综合征（PCOS）女性的氧化应激状态及其与临床和代谢参数的关联。
一项横断面研究。
共纳入544例PCOS患者和468例对照女性。
采用微孔板比色法测定总氧化剂状态（TOS）。还分析了总抗氧化能力（T-AOC）、氧化应激指数（OSI，TOS与T-AOC的比值）以及临床、激素和代谢参数。
根据鹿特丹标准，四种PCOS表型患者的TOS和OSI均显著高于对照女性，高雄激素血症（HA）患者高于无HA患者（P<0.05）。瘦型PCOS患者的TOS、T-AOC和OSI高于瘦型对照（P<0.05）。除OSI外，这些值在超重/肥胖PCOS患者中也高于瘦型患者以及瘦型或超重/肥胖对照（P<0.05）。多因素回归分析表明，载脂蛋白（apo）A1、费里曼-盖尔维评分、甘油三酯（TG）、雌二醇（E）、高密度脂蛋白胆固醇（HDL-C）和2小时血糖水平是TOS的主要预测因素；费里曼-盖尔维评分、E、apoA1、TG和HDL-C水平是OSI的主要预测因素。
与无HA的PCOS患者相比，有HA的患者氧化应激水平更高。PCOS中氧化应激增加与HA状态、血糖、TG、HDL-C和E水平升高、apoA1浓度降低以及抗氧化能力相对不足有关。
