College of Chemistry, Sichuan University , Chengdu 610064, Sichuan, China.
Chengdu Institute of Geology and Mineral Resources , Chengdu 610081, Sichuan, China.
Anal Chem. 2016 Aug 16;88(16):7885-9. doi: 10.1021/acs.analchem.6b02216. Epub 2016 Aug 5.
It is highly attractive to construct a natural enzyme-free electrode for sensitive and selective detection of glucose. In this Letter, we report that a Ni2P nanoarray on conductive carbon cloth (Ni2P NA/CC) behaves as an efficient three-dimensional catalyst electrode for glucose electrooxidation under alkaline conditions. Electrochemical measurements demonstrate that the Ni2P NA/CC, when used as a nonenzymatic glucose sensor, offers superior analytical performances with a short response time of 5 s, a wide detection range of 1 μM to 3 mM, a low detection limit of 0.18 μM (S/N = 3), a response sensitivity of 7792 μA mM(-1) cm(-2), and satisfactory selectivity, specificity, and reproducibility. Moreover, it can also be used for glucose detection in human blood serum, promising its application toward determination of glucose in real samples.
构建用于灵敏和选择性检测葡萄糖的天然无酶电极具有很大吸引力。在本信中，我们报道了在导电碳布上的 Ni2P 纳米阵列（Ni2P NA/CC）在碱性条件下作为葡萄糖电氧化的有效三维催化剂电极。电化学测量表明，Ni2P NA/CC 用作非酶葡萄糖传感器时，具有出色的分析性能，响应时间短至 5 s，检测范围为 1 μM 至 3 mM，检测限低至 0.18 μM（S/N = 3），响应灵敏度为 7792 μA mM(-1) cm(-2)，并且具有令人满意的选择性、特异性和重现性。此外，它还可用于人血清中的葡萄糖检测，有望应用于实际样品中葡萄糖的测定。
