Yücel Yavuz, Coşkun Salih, Cengiz Beyhan, Özdemir Hasan H, Uzar Ertuğrul, Çim Abdullah, Camkurt M Akif, Aluclu M Ufuk
Department of Neurology, Dicle University, Medical Faculty, Diyarbakır, Turkey.
Department of Medical Genetics, Dicle University, Medical Faculty, Diyarbakır, Turkey.
Clin Psychopharmacol Neurosci. 2016 Aug 31;14(3):250-5. doi: 10.9758/cpn.2016.14.3.250.
Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis.
We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (-759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system.
We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group.
This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.
偏头痛是一种高度流行的头痛疾病，被认为是一种多基因多因素疾病。血清素（5-羟色胺，5-HT）及其各自的受体与发病机制有关。
我们调查了土耳其患者中5-HT1A、5-HT1B、5-HT2A和5-HT2C受体基因多态性及其与偏头痛的关联。使用BioMark 96.96动态阵列系统，对135例偏头痛患者和139名健康受试者的rs6295、rs1300060、rs1228814、rs6311、rs6313、rs6314、rs6318、rs3813929（-759C/T）和rs518147多态性进行了分析。
我们发现偏头痛组和对照组之间所分析的9个多态性中的8个多态性频率没有差异。然而，发现5-HTR2C基因启动子区域的rs3813929多态性与偏头痛之间存在显著关联。此外rs3813929的等位基因在偏头痛组中更常见。
该结果表明5-HTR2C rs3813929多态性可能是土耳其人群偏头痛的一个遗传风险因素。
