Lee Seung-Yup, Min Jung-Ah, Lee In Goo, Kim Jung Jin
Department of Psychiatry, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea.
Department of Psychiatry, Seoul St. Mary's Hospital, Seoul, College of Medicine, The Catholic University of Korea, Korea.
Clin Psychopharmacol Neurosci. 2016 Aug 31;14(3):305-10. doi: 10.9758/cpn.2016.14.3.305.
Tuberous sclerosis is not as rare as once thought and has high psychiatric comorbidities. However, bipolar or psychotic features associated with tuberous sclerosis have been rarely reported. This report first presents a tuberous sclerosis patient, resembling a schizoaffective disorder of bipolar type. A patient with known tuberous sclerosis displayed mood fluctuation and psychotic features. Her symptoms did not remit along with several psychiatric medications. After hospitalization, the patient responded well with lamotrigine and aripiprazole without exacerbation. As demonstrated in this case, tuberous sclerosis may also encompass bipolar affective or psychotic features. We would like to point out the necessity to consider bipolarity in evaluating and treating tuberous sclerosis.
结节性硬化症并不像曾经认为的那么罕见，且具有较高的精神疾病共病率。然而，与结节性硬化症相关的双相情感或精神病性特征却鲜有报道。本报告首次呈现了一名类似双相型精神分裂症的结节性硬化症患者。一名已知患有结节性硬化症的患者出现了情绪波动和精神病性特征。她的症状在使用多种精神科药物后并未缓解。住院后，患者对拉莫三嗪和阿立哌唑反应良好，且未出现病情加重。如本病例所示，结节性硬化症也可能包含双相情感或精神病性特征。我们想指出在评估和治疗结节性硬化症时考虑双相情感障碍的必要性。
