自体骨髓间充质细胞诱导软骨形成（MCIC）。
Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC).
作者信息
Huh Sung Woo, Shetty Asode Ananthram, Ahmed Saif, Lee Dong Hwan, Kim Seok Jung
机构信息
Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Republic of Korea.
Canterbury Christ Church University, Faculty of Health and Social Sciences, 30 Pembroke Court, Chatham Maritime, Kent ME4 4UF, United Kingdom.
出版信息
J Clin Orthop Trauma. 2016 Jul-Sep;7(3):153-6. doi: 10.1016/j.jcot.2016.05.004. Epub 2016 Jun 16.
Abstract
Degenerative and traumatic articular cartilage defects are common, difficult to treat, and progressive lesions that cause significant morbidity in the general population. There have been multiple approaches to treat such lesions, including arthroscopic debridement, microfracture, multiple drilling, osteochondral transplantation and autologous chondrocyte implantation (ACI) that are currently being used in clinical practice. Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) is a single-staged arthroscopic procedure. This method combines a modified microfracture technique with the application of a bone marrow aspirate concentrate (BMAC), hyaluronic acid and fibrin gel to treat articular cartilage defects. We reviewed the current literatures and surgical techniques for mesenchymal cell induced chondrogenesis.
摘要
退行性和创伤性关节软骨缺损很常见，难以治疗，且是导致普通人群显著发病的进行性病变。治疗此类病变有多种方法，包括目前临床实践中使用的关节镜清创术、微骨折术、多点钻孔术、骨软骨移植术和自体软骨细胞植入术（ACI）。自体骨髓间充质细胞诱导软骨生成（MCIC）是一种单阶段关节镜手术。该方法将改良的微骨折技术与骨髓抽吸浓缩物（BMAC）、透明质酸和纤维蛋白凝胶的应用相结合，用于治疗关节软骨缺损。我们回顾了间充质细胞诱导软骨生成的当前文献和手术技术。
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