Department of Orthopedic Surgery, Yeungnam University College of Medicine, Yeungnam University Medical Center, 170 Hyonchung-ro, Namgu, Daegu 42415, Korea.
Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea.
Int J Mol Sci. 2020 May 2;21(9):3224. doi: 10.3390/ijms21093224.
Human bone marrow (BM) is a kind of source of mesenchymal stem cells (MSCs) as well as growth factors and cytokines that may aid anti-inflammation and regeneration for various tissues, including cartilage and bone. However, since MSCs in BM usually occupy only a small fraction (0.001%) of nucleated cells, bone marrow aspirate concentrate (BMAC) for cartilage pathologies, such as cartilage degeneration, defect, and osteoarthritis, have gained considerable recognition in the last few years due to its potential benefits including disease modifying and regenerative capacity. Although further research with well-designed, randomized, controlled clinical trials is needed to elucidate the exact mechanism of BMAC, this may have the most noteworthy effect in patients with osteoarthritis. The purpose of this article is to review the general characteristics of BMAC, including its constituent, action mechanisms, and related issues. Moreover, this article aims to summarize the clinical outcomes of BMAC reported to date.
人骨髓（BM）是间充质干细胞（MSCs）以及生长因子和细胞因子的一种来源，这些物质可能有助于各种组织（包括软骨和骨骼）的抗炎和再生。然而，由于 BM 中的 MSCs 通常仅占有核细胞的一小部分（0.001%），因此骨髓抽吸浓缩物（BMAC）在过去几年中因其潜在的益处（包括疾病修饰和再生能力）而在软骨病变（如软骨退变、缺损和骨关节炎）中得到了广泛认可。尽管需要进一步进行设计良好、随机、对照的临床试验来阐明 BMAC 的确切机制，但这可能对骨关节炎患者有最显著的影响。本文的目的是综述 BMAC 的一般特征，包括其组成、作用机制和相关问题。此外，本文旨在总结迄今为止报道的 BMAC 的临床结果。
