Martin Luther Krankenhaus, Caspar Theyß Str. 27-31, 14193, Berlin, Germany.
Knee Surg Sports Traumatol Arthrosc. 2021 Dec;29(12):4213-4222. doi: 10.1007/s00167-021-06513-y. Epub 2021 Mar 20.
The purpose of this study was to perform a systematic review of randomized controlled trials comparing the results of matrix-induced chondrogenesis with other therapies for local chondral lesions of the knee.
A systematic search for randomized controlled trials (RCT) about matrix-induced chondrogenesis for focal chondral lesions in the knee was performed according to the PRISMA guidelines. Data source was PubMed central, EMBASE and Google scholar.
Five articles could be included, whereas two originated from the same study group. Three studies compared matrix-induced chondrogenesis to microfracture (MFx) only. One trial compared AMIC to collagen-covered autologous chondrocyte implantation (ACI-C). One study assessed the improvements given by the combination of AMIC with bone marrow aspirate concentrate (BMAC). In three studies, clinical improvements compared to baseline were seen at 2-year postoperation, irrespective of the technique used. After 5 years, one trial showed better results for the AMIC group compared to MFx, including MRI defect filling. One study showed also good results after AMIC with faster recovery for patients with AMIC + BMAC 12 months postoperatively.
Results of RCTs comparing matrix-induced chondrogenesis with other treatment options showed that matrix-induced chondrogenesis is a valid and safe cartilage repair option for small- to medium-sized cartilage defects of the knee. This one-stage surgical technique presents a good alternative for patients.
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本研究旨在对比较基质诱导软骨形成与其他治疗膝关节局部软骨病变的随机对照试验进行系统回顾。
根据 PRISMA 指南，对膝关节局灶性软骨病变的基质诱导软骨形成的随机对照试验（RCT）进行系统检索。数据来源为 PubMed 中心、EMBASE 和谷歌学术。
可纳入 5 篇文章，其中 2 篇来自同一研究组。3 项研究将基质诱导软骨形成与微骨折（MFx）进行了比较。一项试验将 AMIC 与胶原覆盖的自体软骨细胞移植（ACI-C）进行了比较。一项研究评估了 AMIC 与骨髓抽吸浓缩物（BMAC）联合应用的改善情况。在 3 项研究中，无论使用何种技术，在术后 2 年与基线相比均有临床改善。5 年后，一项试验显示 AMIC 组与 MFx 相比结果更好，包括 MRI 缺损填充。一项研究还显示 AMIC 加 BMAC 后结果良好，术后 12 个月 AMIC+BMAC 患者恢复更快。
比较基质诱导软骨形成与其他治疗选择的 RCT 结果表明，基质诱导软骨形成是一种有效的、安全的膝关节小至中等大小软骨缺损的软骨修复选择。这种一步手术技术为患者提供了一个很好的选择。
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