多发性硬化症治疗中应用干扰素 β1-a 引发类风湿关节炎。两种情况同时出现还是治疗的并发症：病例报告。
Development of rheumatoid arthritis during treatment of multiple sclerosis with interferon beta 1-a. Coincidence of two conditions or a complication of treatment: A case report.
机构信息
Departments of Neurology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran; Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran; Department of Internal Medicine, Division of Rheumatology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
出版信息
J Adv Res. 2016 Sep;7(5):611-3. doi: 10.1016/j.jare.2016.06.004. Epub 2016 Jun 25.
Coexistence of multiple sclerosis (MS) with other autoimmune diseases has been attributed to common background genetic or environmental factors. This study presents development of rheumatoid arthritis (RA) during treatment of MS. The MS was confirmed by the Mc Donald criteria and the diagnosis of RA was confirmed by the ACR/EULAR criteria. A 35 years old women with 9 years of MS who was receiving interferon beta 1-a (INF) for 7 years and who did not respond to conventional therapy of RA over 8 months developed clinical manifestations of RA. But a rapid response was observed after discontinuation of INF. These findings suggest a possible contribution of INF in the development of RA.
多发性硬化症（MS）与其他自身免疫性疾病共存归因于共同的背景遗传或环境因素。本研究报告了在 MS 治疗期间发生类风湿关节炎（RA）的情况。MS 通过 McDonald 标准得到确认，RA 诊断通过 ACR/EULAR 标准得到确认。一名 35 岁女性，患有 9 年 MS，接受干扰素 beta 1-a（INF）治疗 7 年，对 RA 的常规治疗 8 个月以上没有反应，出现 RA 的临床症状。但在停止 INF 治疗后观察到快速反应。这些发现表明 INF 可能有助于 RA 的发展。
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