Gandarias J M, Casis L, Múgica R, Aréchaga G, Ramírez M
Departamento de Fisiología, Facultad de Medicina, Universidad del País Vasco, Bilbao, España.
Rev Esp Fisiol. 1989 Mar;45(1):89-93.
A comparative study of brain aminopeptidase activity between 18 month old male rats and young adults of 3 months has been carried out utilizing the arylamides Leu-, Arg-, Lys-, Tyr- and Asp-beta-naphthylamide as substrates. Statistical analysis of results showed no significant differences either in areas studied or for enzymatic activities detected when both ages were compared. Two different patterns of regional distribution of enzymatic activity were observed: One came to be as a result of the use of Lys-, Arg-, Leu- or Tyr-beta-naphthylamide and the other as a result of the use of Asp-beta-naphthylamide.
利用芳基酰胺亮氨酰 -、精氨酰 -、赖氨酰 -、酪氨酰 - 和天冬氨酰 -β - 萘胺作为底物，对18月龄雄性大鼠和3月龄成年大鼠的脑氨肽酶活性进行了比较研究。结果的统计分析表明，在比较两个年龄段时，所研究的区域或检测到的酶活性均无显著差异。观察到两种不同的酶活性区域分布模式：一种是使用赖氨酰 -、精氨酰 -、亮氨酰 - 或酪氨酰 -β - 萘胺的结果，另一种是使用天冬氨酰 -β - 萘胺的结果。
