Deren Matthew E, Klinge Stephen A, Mukand Nita H, Mukand Jon A
Department of Orthopaedic Surgery, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island.
Wesleyan University, Middletown, Connecticut.
JBJS Rev. 2016 May 17;4(5). doi: 10.2106/JBJS.RVW.15.00072.
Use of statins may be associated with certain tendinopathies and tendon ruptures, especially of the Achilles, quadriceps, and distal biceps tendons. Tendinopathy usually occurs within the first year of statin use and improves after the drug therapy is stopped. Systemic conditions with a higher risk of tendon rupture include diabetes, gout, rheumatoid arthritis, and chronic kidney disease. Certain drugs, such as corticosteroids and fluoroquinolones, have also been implicated in tendon ruptures. Patients with these systemic conditions who are taking statins in combination with other drugs that increase the risk of tendon injury should be educated about this risk and alternative treatments, including diet and exercise.
使用他汀类药物可能与某些肌腱病和肌腱断裂有关，尤其是跟腱、股四头肌和肱二头肌远端肌腱。肌腱病通常在使用他汀类药物的第一年内发生，停药后病情会改善。肌腱断裂风险较高的全身性疾病包括糖尿病、痛风、类风湿性关节炎和慢性肾脏病。某些药物，如皮质类固醇和氟喹诺酮类药物，也与肌腱断裂有关。对于患有这些全身性疾病且正在将他汀类药物与其他增加肌腱损伤风险的药物联合使用的患者，应告知其这种风险以及包括饮食和运动在内的替代治疗方法。
