Alušík Štefan, Paluch Zoltán
Vnitr Lek. 2018 Winter;63(12):967-971.
Tendon injury belongs to the less known side effects of some drugs, reported until recently only for glucocorticoids and fluoroquinolones. To date, some other classes of drugs such as statins, aromatase inhibitors, anabolic steroids, potentially causing tendon injury, have been added to the list. The authors discuss the most common clinical presentations, diagnosis, and management as well as latest experimental data regarding this issue. The most often, the Achilles tendon is affected, however, nearly every tendon of the entire body may be affected. Tendon rupture or drug induced tendinopathy should be strongly considered in those who have a tendon injury and have recently taken these drugs.Key words: anabolic steroids - aromatase inhibitors - fluoroquinolones - glucocorticoids - statins - tendon injury.
肌腱损伤属于某些药物鲜为人知的副作用，直到最近才报道了糖皮质激素和氟喹诺酮类药物会导致这种情况。迄今为止，他汀类药物、芳香化酶抑制剂、合成代谢类固醇等其他一些可能导致肌腱损伤的药物类别也已被列入其中。作者讨论了最常见的临床表现、诊断、治疗以及关于这个问题的最新实验数据。最常受影响的是跟腱，然而，全身几乎每一根肌腱都可能受到影响。对于有肌腱损伤且近期服用过这些药物的患者，应高度怀疑肌腱断裂或药物性肌腱病。关键词：合成代谢类固醇 - 芳香化酶抑制剂 - 氟喹诺酮类 - 糖皮质激素 - 他汀类 - 肌腱损伤
