School of Pharmaceutical Sciences , Wenzhou Medical University , Wenzhou 325035 , People's Republic of China.
State Key Laboratory of Structural Chemistry , Fujian Institute of Research on the Structure of Matter , Chinese Academy of Sciences, Fuzhou , Fujian 350002 , China.
Org Lett. 2019 Feb 1;21(3):745-748. doi: 10.1021/acs.orglett.8b03980. Epub 2019 Jan 14.
The first example of copper-catalyzed four-component coupling reaction of aryl iodides, Se powder, secondary amines, and maleimides is developed. This reaction provides an efficient and concise route to access aminoarylselenated maleimides via double C-Se bonds and C-N bond formation. The appealing features of this transformation are the use of Se powder as a selenating reagent, a green catalytic system, a wide range of substrate scope, and late-stage selenation of bioactive compounds.
发展了首例铜催化的芳基碘、硒粉、仲胺和马来酰亚胺的四组分偶联反应。该反应通过双 C-Se 键和 C-N 键形成，提供了一种高效、简洁的合成氨基芳硒代马来酰亚胺的方法。该转化具有吸引力的特点是使用硒粉作为硒化试剂、绿色催化体系、广泛的底物范围以及生物活性化合物的后期硒化。
