免疫调节药物对调节性T细胞的影响。
Impact of Immune-Modulatory Drugs on Regulatory T Cell.
作者信息
Furukawa Akiko, Wisel Steven A, Tang Qizhi
机构信息
Department of Surgery, University of California, San Francisco, San Francisco, CA, United States.
出版信息
Transplantation. 2016 Nov;100(11):2288-2300. doi: 10.1097/TP.0000000000001379.
Abstract
Immunosuppression strategies that selectively inhibit effector T cells while preserving and even enhancing CD4FOXP3 regulatory T cells (Treg) permit immune self-regulation and may allow minimization of immunosuppression and associated toxicities. Many immunosuppressive drugs were developed before the identity and function of Treg were appreciated. A good understanding of the interactions between Treg and immunosuppressive agents will be valuable to the effective design of more tolerable immunosuppression regimens. This review will discuss preclinical and clinical evidence regarding the influence of current and emerging immunosuppressive drugs on Treg homeostasis, stability, and function as a guideline for the selection and development of Treg-friendly immunosuppressive regimens.
摘要
选择性抑制效应T细胞同时保留甚至增强CD4FOXP3调节性T细胞（Treg）的免疫抑制策略可实现免疫自我调节，并可能使免疫抑制及其相关毒性降至最低。许多免疫抑制药物是在Treg的特性和功能被认识之前开发的。深入了解Treg与免疫抑制药物之间的相互作用，对于有效设计更具耐受性的免疫抑制方案具有重要价值。本综述将讨论有关当前和新兴免疫抑制药物对Treg稳态、稳定性和功能影响的临床前和临床证据，作为选择和开发有利于Treg的免疫抑制方案的指导原则。
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